Spellcheck nemesis Liev Schreiber is reportedly in talks to play bad guy William Stryker in what is now called X-Men Origins: Wolverine, due for release on May 1, 2009.
The release date is good news, indicating as it does that the studio (Fox) sees the film as a big summer tentpole release. And Schreiber's casting would be fine - sure, he looks nothing like Bryan Cox, but he's got a deep enough voice to match up a little, at least, and the presence to make a sufficiently formidable boss / adversary.
Further mutants are yet to be cast, but will include some we've already seen in "one or more" of the three X-Men films. Those mutants will certainly include Sabertooth, since his alter-ego Victor Creed is a big part of the plot, and could include any number of other bad-guy mutants (Toad, Mystique, Calypso, Lady Deathstrike, Jason Stryker) and possibly Professor Xavier, but shouldn't, logically, include any other X-Men, since they clearly met our hero for the first time at the beginning for the first movie.
But that unwieldy title is a whole other ballgame - do we really need Wolverine tied in so obviously with the franchise?