It would be far too easy to make jokes here about Milla Jovovich having the Bad Luck to work with the director of Snakes on a Plane, so we probably shouldn't have. But yes, the supreme being and Resident Evil star is set to appear in David R. Ellis' story about superstition.
She'll play one of a group of college friends (we think that means "friends since college" not "friends in college") who find their lives changed when superstitions begin to come true. Cue people first scoffing and then panicking when a black cat runs in front of them / they inadvertantly subnavigate a ladder / they spill sugar. We're guessing that this could have a Final Destination sort of a vibe.
Ellis is working on a couple of other films first, however: Shark Night, in 3D, which shoots this summer in Louisiana; a film called War Monkeys which apparently literally involves monkeys with guns, and The Genesis Code** with Hayden Christensen. In other words, don't hold your breath for this one just yet.